C₂₁H₁₈ClF₅O₆S₂

Base Information

• Chemical Name: C₂₁H₁₈ClF₅O₆S₂
• CAS No.: 1100361-37-2
• Molecular Formula: C₂₁H₁₈ClF₅O₆S₂
• Molecular Weight: 560.947
• Mol file: 1100361-37-2.mol

Synonyms:C₂₁H₁₈ClF₅O₆S₂

Chemical Property of C₂₁H₁₈ClF₅O₆S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₈ClF₅O₆S₂

There total 9 articles about C₂₁H₁₈ClF₅O₆S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C27H25ClF2O7S2 (1100361-35-0) + Langlois reagent (2926-29-6) → C21H18ClF5O6S2 (1100361-37-2)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2012.11.047

Reference yield:

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol (944950-53-2) → C21H18ClF5O6S2 (1100361-37-2)

Guidance literature:

Multi-step reaction with 11 steps

1: potassium tert-butylate / tetrahydrofuran

2: Dess-Martin periodane / dichloromethane

3: trimethylsilyl trifluoromethanesulfonate

4: boron trifluoride diethyl etherate / dichloromethane

5: oxone / acetone; water

6: triethylamine / dichloromethane

7: potassium tert-butylate / tetrahydrofuran

8: ozone / dichloromethane

9: Resolution of racemate

10: triethylamine

11: tetra-(n-butyl)ammonium iodide / tetrahydrofuran

With oxone; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; Dess-Martin periodane; ozone; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone;

DOI:10.1016/j.bmcl.2012.11.047

Reference yield:

2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester (944950-33-8) → C21H18ClF5O6S2 (1100361-37-2)

Guidance literature:

Multi-step reaction with 13 steps

1: potassium carbonate / tetrahydrofuran

2: lithium aluminium tetrahydride / tetrahydrofuran

3: potassium tert-butylate / tetrahydrofuran

4: Dess-Martin periodane / dichloromethane

5: trimethylsilyl trifluoromethanesulfonate

6: boron trifluoride diethyl etherate / dichloromethane

7: oxone / acetone; water

8: triethylamine / dichloromethane

9: potassium tert-butylate / tetrahydrofuran

10: ozone / dichloromethane

11: Resolution of racemate

12: triethylamine

13: tetra-(n-butyl)ammonium iodide / tetrahydrofuran

With oxone; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; potassium carbonate; Dess-Martin periodane; ozone; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone; 1: |Michael Addition;

DOI:10.1016/j.bmcl.2012.11.047

upstream raw materials:

C₂₇H₂₅ClF₂O₇S₂

Langlois reagent

2-[(4-chloro-phenylsulfanyl)-(2,3,6-trifluoro-phenyl)-methyl]-propane-1,3-diol

2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester