(4-chlorophenyl)-(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone

Base Information

Chemical Name:(4-chlorophenyl)-(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone
CAS No.:1380089-22-4
Molecular Formula:C₁₈H₁₄ClNO₃
Molecular Weight:327.767
Hs Code.:

Synonyms:(4-chlorophenyl)-(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone

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Chemical Property of (4-chlorophenyl)-(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone

Chemical Property:

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Technology Process of (4-chlorophenyl)-(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone

There total 5 articles about (4-chlorophenyl)-(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380089-20-2
4-(2-(4-chlorobenzyl)phenyl)-3-methylisoxazol-5-ylmethyl benzoate

: 1380089-22-4
(4-chlorophenyl)-(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 0 ℃; for 1h;

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1380089-22-4
(4-chlorophenyl)-(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.5 h / 0 °C

2: triethylamine; oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

3: potassium carbonate; water / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere; Resealable vial

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dimethyl sulfoxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 1380089-22-4
(4-chlorophenyl)-(2-(5-(hydroxymethyl)-3-methylisoxazol-4-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.5 h / 0 °C

2: triethylamine; oxalyl dichloride / dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

3: potassium carbonate; water / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 110 °C / Inert atmosphere; Resealable vial

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dimethyl sulfoxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;