5,7-dihydroxy-3,4-diphenyl-coumarin

Base Information

• Chemical Name: 5,7-dihydroxy-3,4-diphenyl-coumarin
• CAS No.: 80472-57-7
• Molecular Formula: C₂₁H₁₄O₄
• Molecular Weight: 330.34
• Mol file: 80472-57-7.mol

Synonyms:5,7-dihydroxy-3,4-diphenyl-coumarin

Chemical Property of 5,7-dihydroxy-3,4-diphenyl-coumarin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,7-dihydroxy-3,4-diphenyl-coumarin

There total 3 articles about 5,7-dihydroxy-3,4-diphenyl-coumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzoylphloroglucinol (3555-86-0) + phenylacetyl chloride (103-80-0) → 5,7-dihydroxy-3,4-diphenyl-coumarin (80472-57-7)

Guidance literature:

With potassium hydroxide; potassium carbonate; Yield given. Multistep reaction; 1.) acetone, reflux, 6 h, 2.) methanol, reflux, 15 min;

DOI:10.1055/s-1981-29633

Reference yield:

5,7-diacetoxy-3,4-diphenyl-coumarin → 5,7-dihydroxy-3,4-diphenyl-coumarin (80472-57-7)

Guidance literature:

With sulfuric acid;

Reference yield:

sodium phenylacetate (114-70-5) → 5,7-dihydroxy-3,4-diphenyl-coumarin (80472-57-7)

Guidance literature:

Multi-step reaction with 2 steps

2: sulfuric acid

With sulfuric acid;

upstream raw materials:

2-benzoylphloroglucinol

phenylacetyl chloride

sodium phenylacetate

Downstream raw materials:

5,7-Dimethoxy-3,4-diphenyl-chromen-2-one

Refernces