4-benzyloxy-(R)-2-(4-tert-butoxycarbonylmethyl-2-(R)-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid

Base Information

• Chemical Name: 4-benzyloxy-(R)-2-(4-tert-butoxycarbonylmethyl-2-(R)-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid
• CAS No.: 1073132-14-5
• Molecular Formula: C₂₄H₃₄O₈
• Molecular Weight: 450.529

Synonyms:4-benzyloxy-(R)-2-(4-tert-butoxycarbonylmethyl-2-(R)-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid

Chemical Property of 4-benzyloxy-(R)-2-(4-tert-butoxycarbonylmethyl-2-(R)-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid

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Technology Process of 4-benzyloxy-(R)-2-(4-tert-butoxycarbonylmethyl-2-(R)-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid

There total 1 articles about 4-benzyloxy-(R)-2-(4-tert-butoxycarbonylmethyl-2-(R)-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 4-benzyloxy-(R)-2-((R)-2-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid (1073132-15-6) → 4-benzyloxy-(R)-2-(4-tert-butoxycarbonylmethyl-2-(R)-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid (1073132-14-5)

Guidance literature:

4-benzyloxy-(R)-2-((R)-2-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid; With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -70 ℃; for 0.833333h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; at -70 ℃; for 0.25h; diastereoselective reaction;

DOI:10.1021/jo801708q

Reference yield: 90.0%

methanol (67-56-1) + 4-benzyloxy-(R)-2-(4-tert-butoxycarbonylmethyl-2-(R)-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid (1073132-14-5) → C18H24O8 (1144031-38-8)

Guidance literature:

With boron trifluoride diethyl etherate; Reflux;

DOI:10.1016/j.tetlet.2009.01.057

Reference yield:

4-benzyloxy-(R)-2-(4-tert-butoxycarbonylmethyl-2-(R)-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid (1073132-14-5) → C20H26O8 (1073132-20-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; toluene; at 0 - 20 ℃;

DOI:10.1021/jo801708q

upstream raw materials:

bromoacetic acid tert-butyl ester

4-benzyloxy-(R)-2-((R)-2-tert-butyl-(R)-5-oxo-[1,3]dioxolan-4-yl)butyric acid

Downstream raw materials:

C₂₀H₂₆O₈

C₁₈H₂₄O₈

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