phenyloctyl methanesulfonate

Base Information

• Chemical Name: phenyloctyl methanesulfonate
• CAS No.: 1421864-49-4
• Molecular Formula: C₁₅H₂₄O₃S
• Molecular Weight: 284.42
• Mol file: 1421864-49-4.mol

Synonyms:phenyloctyl methanesulfonate

Chemical Property of phenyloctyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of phenyloctyl methanesulfonate

There total 1 articles about phenyloctyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

8-phenyloctan-1-ol (10472-97-6) + methanesulfonyl chloride (124-63-0) → phenyloctyl methanesulfonate (1421864-49-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 4h;

DOI:10.1016/j.bmcl.2012.10.093

Reference yield: 96.0%

phenyloctyl methanesulfonate (1421864-49-4) → (8-azidooctyl)benzene (76264-80-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 10h;

DOI:10.1016/j.bmcl.2012.10.093

Reference yield:

phenyloctyl methanesulfonate (1421864-49-4) → benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate (1415221-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium azide / N,N-dimethyl-formamide / 10 h / 60 °C

2.1: magnesium / methanol / 1 h / 0 °C

3.1: HATU; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With sodium azide; benzotriazol-1-ol; magnesium; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.10.093

upstream raw materials:

8-phenyloctan-1-ol

methanesulfonyl chloride

Downstream raw materials:

(8-azidooctyl)benzene

8--phenyloctan--1--amine

benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate

N--Fmoc--(2S)-2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoic acid