benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate

Base Information

Chemical Name:benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate
CAS No.:1415221-95-2
Molecular Formula:C₄₀H₄₄N₂O₅
Molecular Weight:632.8
Hs Code.:

Synonyms:benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate

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Chemical Property of benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate

Chemical Property:

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Technology Process of benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate

There total 5 articles about benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17734-23-5
8--phenyloctan--1--amine

: 86060-83-5
N-(9-fluorenylmethoxycarbonyl)-L-aspartyl α-benzyl ester

: 1415221-95-2
benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate

Guidance literature:: N-(9-fluorenylmethoxycarbonyl)-L-aspartyl α-benzyl ester; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

8--phenyloctan--1--amine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.10.093

Reference yield:

: 1421864-49-4
phenyloctyl methanesulfonate

: 1415221-95-2
benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / N,N-dimethyl-formamide / 10 h / 60 °C

2.1: magnesium / methanol / 1 h / 0 °C

3.1: HATU; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With sodium azide; benzotriazol-1-ol; magnesium; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.093

Reference yield:

: 10472-97-6
8-phenyloctan-1-ol

: 1415221-95-2
benzyl N--Fmoc--(2S)--2--amino--4--oxo--4--((8--phenyloctyl)amino)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 4 h

2.1: sodium azide / N,N-dimethyl-formamide / 10 h / 60 °C

3.1: magnesium / methanol / 1 h / 0 °C

4.1: HATU; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With sodium azide; benzotriazol-1-ol; magnesium; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.093