[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid

Base Information

• Chemical Name: [2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid
• CAS No.: 566202-72-0
• Molecular Formula: C₂₂H₁₉BrO₄
• Molecular Weight: 427.294
• Mol file: 566202-72-0.mol

Synonyms:[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid

Chemical Property of [2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid

There total 8 articles about [2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

1-(4-benzyloxybenzyloxy)-2-allyl-4-bromobenzene (566202-90-2) → [2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid (566202-72-0)

Guidance literature:

With sodium periodate; ruthenium(III) chloride trihydrate; In tetrachloromethane; water; acetonitrile; for 18h;

Reference yield:

[2-(4-benzyloxy-benzyloxy)-5-bromo-phenyl]-acetaldehyde → [2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid (566202-72-0)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol;

DOI:10.1055/s-2003-39316

Reference yield:

4-benzyloxybenzyl chloride (836-42-0) → [2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid (566202-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 95 percent / K₂CO₃ / dimethylformamide / 4 h / 60 °C

2.1: O₃ / CH₂Cl₂; methanol / 7.5 h / -78 °C

2.2: Me₂S / CH₂Cl₂; methanol / -78 - 20 °C

3.1: 137 g / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 84 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; potassium carbonate; ozone; In methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.tet.2004.06.144

upstream raw materials:

p-benzyloxybenzaldehyde

4-benzyloxybenzyl alcohol

benzyl bromide

4-hydroxy-benzaldehyde

Downstream raw materials:

[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid methyl ester

(1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester

(-)-ephedradine A

[2-(4-benzyloxybenzyloxy)-5-bromophenyl]diazoacetic acid methyl ester