566202-90-2

Upstream product

• 13997-74-5 2-allyl-4-bromophenol 
• 836-42-0 4-benzyloxybenzyl chloride 
• 5544-60-5 4-(benzyloxy)benzyl bromide 
• 100-39-0 benzyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 836-43-1 4-benzyloxybenzyl alcohol 
• 4397-53-9 p-benzyloxybenzaldehyde 

Downstream Products

• 795296-98-9 (R)-2-{2-[2-(4-Benzyloxy-benzyloxy)-5-bromo-phenyl]-2-diazo-acetoxy}-propionic acid methyl ester 
• 795297-02-8 (R)-2-{2-[2-(4-Benzyloxy-benzyloxy)-5-bromo-phenyl]-acetoxy}-propionic acid methyl ester 
• 616898-42-1 [2-(4-Benzyloxy-benzyloxy)-5-bromo-phenyl]-diazo-acetic acid (S)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester 
• 616898-41-0 2-{[2-(4-benzyloxybenzyloxy)-5-bromophenyl]diazoacetoxy}propionic acid methyl ester 
• 566203-00-7 (3R,2'R,3'R)-3-[3'-{(3''-acetoxypropyl)-[4''-(tert-butyldiphenylsilanyloxy)butyl]carbamoyl}-2'-(4''-benzyloxyphenyl)-2',3'-dihydrobenzofuran-5'-yl]-3-{benzyloxycarbonyl-[3'-(2''-nitrobenzenesulfonylamino)propyl]amino}propionic acid methyl ester 
• 566202-85-5 3-(3-azidopropyl)-19-(4-benzyloxyphenyl)-13-pentafluorophenoxycarbonylmethyl-8-(2-nitrobenzenesulfonyl)-2-oxo-18-oxa-3,8,12-triazatricyclo[12.5.2.0^0.0]heneicosa-14⁽²¹⁾,15,17⁽²⁰⁾-triene-12-carboxylic acid benzyl ester 
• 566202-97-9 (3R,2'R,3'R)-3-[3'-{(3''-acetoxypropyl)-[4''-(tert-butyldiphenylsilanyloxy)butyl]carbamoyl}-2'-(4''-benzyloxyphenyl)-2',3'-dihydrobenzofuran-5'-yl]-3-(2''-nitrobenzenesulfonyl-[3'-(tert-butyldimethylsilanyloxy)propyl]amino)propionic acid methyl ester 
• 566202-82-2 (3R,2'R,3'R)-3-[3'-{(3''-acetoxypropyl)-[4''-(tert-butyldiphenylsilanyloxy)butyl]carbamoyl}-2'-(4''-benzyloxyphenyl)-2',3'-dihydrobenzofuran-5'-yl]-3-{benzyloxycarbonyl-[3'-(tert-butyldimethylsilanyloxy)propyl]amino}propionic acid methyl ester 
• 566202-99-1 (3R,2'R,3'R)-3-[3'-{(3''-acetoxypropyl)-[4''-(tert-butyldiphenylsilanyloxy)butyl]carbamoyl}-2'-(4''-benzyloxyphenyl)-2',3'-dihydrobenzofuran-5'-yl]-3-[benzyloxycarbonyl-(3'-hydroxypropyl)amino]propionic acid methyl ester 
• 566202-98-0 (3R,2'R,3'R)-3-[3'-{(3''-acetoxypropyl)-[4''-(tert-butyldiphenylsilanyloxy)butyl]carbamoyl}-2'-(4''-benzyloxyphenyl)-2',3'-dihydrobenzofuran-5'-yl]-3-[3'-(tert-butyldimethylsilanyloxy)propylamino]propionic acid methyl ester 
• 566202-81-1 (3R,2'R,3'R)-3-[3'-{(3''-acetoxypropyl)-[4''-(tert-butyldiphenylsilanyloxy)butyl]carbamoyl}-2'-(4''-benzyloxyphenyl)-2',3'-dihydrobenzofuran-5'-yl]-3-(2-nitrobenzenesulfonylamino)propionic acid methyl ester 
• 566202-83-3 (3R,2'R,3'R)-3-[3'-[(3''-acetoxypropyl)-(4''-hydroxybutyl)carbamoyl]-2'-(4''-benzyloxyphenyl)-2',3'-dihydrobenzofuran-5'-yl]-3-{benzyloxycarbonyl-[3'-(2''-nitrobenzenesulfonylamino)propyl]amino}propionic acid methyl ester 
• 566202-80-0 (2S,3R,2'R,3'R)-3-[3'-{(3''-acetoxypropyl)-[4''-(tert-butyldiphenylsilanyloxy)butyl]carbamoyl}-2'-(4-benzyloxyphenyl)-2',3'-dihydrobenzofuran-5'-yl]-3-benzyloxycarbonylamino-2-hydroxypropionic acid methyl ester 
• 566202-84-4 (13R,19R,20R)-3-(3'-acetoxypropyl)-19-(4'-benzyloxyphenyl)-13-methoxycarbonylmethyl-8-(2'-nitrobenzenesulfonyl)-2-oxo-18-oxa-3,8,12-triazatricyclo[12.5.2.0^0.0]heneicosa-14⁽²¹⁾,15,17⁽²⁰⁾-triene-12-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

COMPOUND, ALPHA 1 ADRENALINE RECEPTOR ANTAGONIST, AND COMPOSITION

A novel compound, a novel α1 adrenergic receptor antagonistic agent, and a novel composition are provided which are capable of exerting a therapeutic effect on treatment of hypertension as well as treatment of prostatic hypertrophy and the like. The compound is represented by the following formula (1):

Total synthesis of (-)-ephedradine A: An efficient construction of optically active dihydrobenzofuran-ring via C-H insertion reaction

The stereocontrolled total synthesis of (-)-ephedradine A (1) has been accomplished. Construction of optically active dihydrobenzofuran-ring was performed by a novel asymmetric C-H insertion reaction. After an intramolecular ester-amide exchange reaction and a Sharpless asymmetric aminohydroxylation reaction, construction of the complex macrocyclic ring was performed by Ns-strategy and an intramolecular aza-Wittig reaction. Graphical Abstract.

Stereocontrolled total synthesis of (-)-ephedradine a (orantine)

The stereocontrolled total synthesis of (-)-ephedradine A has been accomplished. The synthesis features an asymmetric C-H insertion reaction, an intramolecular ester-amide exchange reaction, and a Sharpless asymmetric aminohydroxylation reaction. Construction of the complex macrocyclic ring was performed by Ns-strategy and an intramolecular aza-Wittig reaction. Copyright

An efficient synthesis of optically active trans-2-Aryl-2,3-dihydrobenzofuran-3-carboxylic acid esters via C-H insertion reaction

Optically active trans-2-Aryl-2,3-dihydrobenzofuran-3-carboxylic acid esters were synthesized by intramolecular C-H insertion reaction. Upon treatment with a catalytic amount of Rh2(R-DOSP)4, aryldiazoester 8c possessing a chiral auxiliary underwent C-H insertion reaction to give 9c in high yield and in high selectivity (84% yield, 86% de).