(1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester

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Chemical Name:(1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester
CAS No.:566202-91-3
Molecular Formula:C₂₉H₃₀BrNO₅
Molecular Weight:552.465
Hs Code.:

Synonyms:(1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester

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Chemical Property of (1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester

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Technology Process of (1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester

There total 11 articles about (1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 122151-38-6
(S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one

: 566202-72-0
[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid

: 566202-91-3
(1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 0 - 20 ℃; for 2h;
DOI:10.1021/ja036011k

Reference yield:

: 836-42-0
4-benzyloxybenzyl chloride

: 566202-91-3
(1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / K₂CO₃ / dimethylformamide / 4 h / 60 °C

2.1: O₃ / CH₂Cl₂; methanol / 7.5 h / -78 °C

2.2: Me₂S / CH₂Cl₂; methanol / -78 - 20 °C

3.1: 137 g / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 84 h / 20 °C

4.1: 80 percent / diethyl azodicarboxylate; PPh₃ / toluene / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; potassium carbonate; ozone; triphenylphosphine; diethylazodicarboxylate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 4.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2004.06.144

Reference yield:

: [2-(4-benzyloxy-benzyloxy)-5-bromo-phenyl]-acetaldehyde

: 566202-91-3
(1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 137 g / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 84 h / 20 °C

2: 80 percent / diethyl azodicarboxylate; PPh₃ / toluene / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; triphenylphosphine; diethylazodicarboxylate; In water; toluene; tert-butyl alcohol; 2: Mitsunobu reaction;
DOI:10.1016/j.tet.2004.06.144