methyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate

Base Information

Chemical Name:methyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate
CAS No.:164577-01-9
Molecular Formula:C₆H₁₀O₃
Molecular Weight:130.144
Hs Code.:
European Community (EC) Number:851-978-8

Synonyms:methyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate;164577-01-9;83680-85-7;SCHEMBL2966759;QMFFTUAKXYCOKM-UHNVWZDZSA-N;MFCD30802343;PS-16293;CS-0056044;P20219;EN300-7327830;methyl (1S,2S)-2-(hydroxymethyl)cyclopropanecarboxylate;methyl(1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate

Suppliers and Price of methyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of methyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate

Chemical Property:

XLogP3:-0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:130.062994177
Heavy Atom Count:9
Complexity:122

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1CC1CO
Isomeric SMILES:COC(=O)[C@H]1C[C@@H]1CO

Technology Process of methyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate

There total 1 articles about methyl (1S,2S)-2-(hydroxymethyl)cyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 164577-01-9
(1S,2S)-methyl 2-(hydroxymethyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap / tetrahydrofuran / 4 h / 0 - 20 °C

2: methanol / 1.5 h / 20 °C

3: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; hexane / 3.03 h / -78 - 0 °C / Inert atmosphere

With pyridine; dmap; n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane;

Reference yield: 50.0%

: 164577-01-9
(1S,2S)-methyl 2-(hydroxymethyl)cyclopropanecarboxylate

: 35501-84-9
(+)-(1S,2S) methyl 2-formylcyclopropanecarboxylate

Guidance literature:: With pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/0957-4166(95)00060-3

Reference yield: 36.0%

: 100-39-0
benzyl bromide

: 164577-01-9
(1S,2S)-methyl 2-(hydroxymethyl)cyclopropanecarboxylate

: methyl (1S,2S)-2-((benzyloxy)methyl)cyclopropanecarboxylate

Guidance literature:: (1S,2S)-methyl 2-(hydroxymethyl)cyclopropanecarboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 15h;