5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide

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Chemical Name:5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide
CAS No.:201146-04-5
Molecular Formula:C₁₈H₂₂ClN₅O₃
Molecular Weight:391.857
Hs Code.:

Synonyms:5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide

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Chemical Property of 5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide

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Technology Process of 5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide

There total 2 articles about 5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 201145-98-4
N-[4-(4-Chloro-phenylcarbamoyl)-3-methyl-isoxazol-5-yl]-formimidic acid methyl ester

: 201146-04-5
5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide

Guidance literature:: In ethanol; for 2h; Heating;
DOI:10.1002/ardp.19973301102

Reference yield:

: 84661-32-5
5-amino-3-methyl-4-isoxazolecarboxylic acid 4'-chlorophenyl amide

: 201146-04-5
5-{[1-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-meth-(E)-ylidene]-amino}-3-methyl-isoxazole-4-carboxylic acid (4-chloro-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 62.9 percent / toluene / 2 h / Heating

2: 63 percent / 2 h / Heating

3: 64 percent / ethanol / 2 h / Heating

In ethanol; toluene;
DOI:10.1002/ardp.19973301102