3-[2-(2-BROMO-4-CHLOROPHENYL)ETHYL]-5-METHYL-2-THIOPHENECARBALDEHYDE

Base Information

• Chemical Name: 3-[2-(2-BROMO-4-CHLOROPHENYL)ETHYL]-5-METHYL-2-THIOPHENECARBALDEHYDE
• CAS No.: 78348-00-2
• Molecular Formula: C₁₄H₁₂BrClOS
• Molecular Weight: 343.672
• Mol file: 78348-00-2.mol

Synonyms:3-<2-(2'-bromo-4'-chlorophenyl)ethyl>-5-methyl-2-thiophenecarboxaldehyde

Chemical Property of 3-[2-(2-BROMO-4-CHLOROPHENYL)ETHYL]-5-METHYL-2-THIOPHENECARBALDEHYDE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(2-BROMO-4-CHLOROPHENYL)ETHYL]-5-METHYL-2-THIOPHENECARBALDEHYDE

There total 5 articles about 3-[2-(2-BROMO-4-CHLOROPHENYL)ETHYL]-5-METHYL-2-THIOPHENECARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 4-<2-(2'-bromo-4'-chlorophenyl)ethyl>-2-methylthiophene (78347-94-1) → 3-<2-(2'-bromo-4'-chlorophenyl)ethyl>-5-methyl-2-thiophenecarboxaldehyde (78348-00-2)

Guidance literature:

With trichlorophosphate; at 75 ℃; for 0.5h;

Reference yield:

2-methyl-4-thiophenecarboxaldehyde (29421-72-5) → 3-<2-(2'-bromo-4'-chlorophenyl)ethyl>-5-methyl-2-thiophenecarboxaldehyde (78348-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / sodium methoxide / dimethylformamide / 1.75 h / 0 - 20 °C

2: 77 percent / tristriphenylphosphine rhodium(I) chloride, H₂ / ethanol / 4 h / 60 - 70 °C / 1551.4 - 3102.9 Torr

3: 92 percent / phosphorus oxychloride / 0.5 h / 75 °C

With Wilkinson's catalyst; hydrogen; sodium methylate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

2-bromo-4-chlorobenzyl bromide (33924-45-7) → 3-<2-(2'-bromo-4'-chlorophenyl)ethyl>-5-methyl-2-thiophenecarboxaldehyde (78348-00-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / 3 h / 120 - 150 °C

2: 97 percent / sodium methoxide / dimethylformamide / 1.75 h / 0 - 20 °C

3: 77 percent / tristriphenylphosphine rhodium(I) chloride, H₂ / ethanol / 4 h / 60 - 70 °C / 1551.4 - 3102.9 Torr

4: 92 percent / phosphorus oxychloride / 0.5 h / 75 °C

With Wilkinson's catalyst; hydrogen; sodium methylate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

N,N-dimethyl-formamide

4-<2-(2'-bromo-4'-chlorophenyl)ethyl>-2-methylthiophene

2-methyl-4-thiophenecarboxaldehyde

2-bromo-4-chlorobenzyl bromide