methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Base Information

• Chemical Name: methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
• CAS No.: 1062169-58-7
• Molecular Formula: C₂₂H₂₇N₇O₃
• Molecular Weight: 437.501
• Mol file: 1062169-58-7.mol

Synonyms:methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Chemical Property of methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

There total 1 articles about methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-(6-chloro-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid methyl ester (1062173-85-6) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) → methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate (1062169-58-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 16h; Reflux;

DOI:10.1021/jm9013828

Reference yield: 63.0%

bis(trichloromethyl) carbonate (32315-10-9) + methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate (1062169-58-7) + ethylene glycol (107-21-1) → methyl 4-[6-(4-([(2-hydroxyethoxy)carbonyl]amino)phenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate (1062172-39-7)

Guidance literature:

bis(trichloromethyl) carbonate; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate; With triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;

ethylene glycol; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm900851f

Reference yield: 54.0%

bis(trichloromethyl) carbonate (32315-10-9) + methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate (1062169-58-7) + 4-aminobenzenemethanol (623-04-1) → methyl 4-(6-(4-(3-(4-(hydroxymethyl)phenyl)ureido)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate (1062172-60-4)

Guidance literature:

bis(trichloromethyl) carbonate; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

4-aminobenzenemethanol; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm900851f

upstream raw materials:

4-(6-chloro-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid methyl ester

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

Downstream raw materials:

methyl 4-(6-(4-(3-(4-fluorophenyl)ureido)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

methyl 4-(4-morpholino-6-(4-(phenoxycarbonylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

methyl 4-(4-morpholin-4-yl-6-(4-[(pyridin-3-ylcarbamoyl)amino]phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

methyl 4-(4-morpholin-4-yl-6-(4-[(pyridin-4-ylcarbamoyl)amino]phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate