N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)hex-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)hex-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide
CAS No.:1602922-98-4
Molecular Formula:C₂₈H₃₂N₂O₆S₂
Molecular Weight:556.704
Hs Code.:

Synonyms:N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)hex-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide

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Chemical Property of N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)hex-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide

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Technology Process of N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)hex-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide

There total 4 articles about N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)hex-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1602922-96-2
C₂₇H₂₈N₂O₆S₂

: 75-16-1
methylmagnesium bromide

: 1602922-98-4
N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)hex-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/jo500308y

Reference yield:

: 1602922-82-6
N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)pent-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide

: 1602922-98-4
N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)hex-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With manganese(IV) oxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo500308y

Reference yield:

: 161040-05-7
N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide

: 1602922-98-4
N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)hex-3-yn-1-yl)-N-(4-methoxybenzyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 60 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With manganese(IV) oxide; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/jo500308y