rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide

Base Information

Chemical Name:rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide
CAS No.:1236301-66-8
Molecular Formula:C₂₂H₂₅F₃N₂O₂S
Molecular Weight:438.514
Hs Code.:

Synonyms:rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide

Suppliers and Price of rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide

There total 5 articles about rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1236302-33-2
rac-1-methyl-3-phenyl-piperidin-3-ylamine

: 1236303-05-1
2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoyl chloride

: 1236301-66-8
rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ml500005m

Reference yield:

: 61995-20-8
N-(benzyloxycarbonyl)-3-piperidone

: 1236301-66-8
rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.75 h / 20 °C

2: sodium azide / water; trifluoroacetic acid / 3 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 65 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With lithium aluminium tetrahydride; sodium azide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; trifluoroacetic acid;
DOI:10.1021/ml500005m

Reference yield:

: 1236302-32-1
rac-3-azido-3-phenyl-piperidine-1-carboxylic acid benzyl ester

: 1236301-66-8
rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-6-methylsulfanyl-4-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 10 - 65 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml500005m