tert-butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate
CAS No.:1299488-11-1
Molecular Formula:C₂₂H₃₅FN₄O₃
Molecular Weight:422.543
Hs Code.:

Synonyms:tert-butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1299487-74-3
tert-butyl 4-(4-amino-3-fluorobenzyl)piperidine-1-carboxylate

: 7693-46-1
4-Nitrophenyl chloroformate

: 811-93-8
1,1-dimethylethylenediamine

: 1299488-11-1
tert-butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-(4-amino-3-fluorobenzyl)piperidine-1-carboxylate; 4-Nitrophenyl chloroformate; In tetrahydrofuran; at 20 ℃; for 1h;

1,1-dimethylethylenediamine; With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 131858-37-2
4-(bromomethyl)-2-fluoro-1-nitrobenzene

: 1299488-11-1
tert-butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4 h / 140 °C

2.1: sodium hydride / tetrahydrofuran; oil / 4 h

3.1: potassium fluoride / palladium diacetate / tetrahydrofuran / 1 h / 20 °C / Sealed tube; Inert atmosphere

4.1: tetrahydrofuran / 1 h / 20 °C

4.2: 20 °C

With potassium fluoride; sodium hydride; palladium diacetate; In tetrahydrofuran; oil;

Reference yield:

: 1132941-95-7
3-fluoro-4-nitrobenzyl phosphonate

: 1299488-11-1
tert-butyl 4-(4-(3-(2-amino-2-methylpropyl)ureido)-3-fluorobenzyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; oil / 4 h

2.1: potassium fluoride / palladium diacetate / tetrahydrofuran / 1 h / 20 °C / Sealed tube; Inert atmosphere

3.1: tetrahydrofuran / 1 h / 20 °C

3.2: 20 °C

With potassium fluoride; sodium hydride; palladium diacetate; In tetrahydrofuran; oil;