385844-15-5

Basic information

• Product Name: 4-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-a-(4-fluorophenyl)-1,2,3,6-tetrahydro-
• CAS NO: 385844-15-5
• Molecular Formula: C18H22FNO4
• Molecular Weight: 335.375
• Mol File: 385844-15-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-a-(4-fluorophenyl)-1,2,3,6-tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-a-(4-fluorophenyl)-1,2,3,6-tetrahydro-(385844-15-5)
• EPA Substance Registry System: 4-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-a-(4-fluorophenyl)-1,2,3,6-tetrahydro-(385844-15-5)

Safety Data

• Hazardous Substances Data: 385844-15-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 385844-14-4 (+/-)-[1-(tert-butoxycarbonyl)-4-hydroxypiperidin-4-yl](4-fluorophenyl)acetic acid 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 405-50-5 p-Fluorophenylacetic acid 
• 123-91-1 1,4-dioxane 

Downstream Products

• 385844-24-6 1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine 
• 385844-17-7 tert-butyl 4-(1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}-2-oxoethyl)piperidine-1-carboxylate 
• 929268-62-2 4-{1-(4-fluoro-phenyl)-2-[4-(4-naphthalen-1-yl-butyl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 929268-72-4 3-(3'-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-68-8 3-(3-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-70-2 3-(2'-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-66-6 3-(5-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-67-7 3-(4-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-65-5 3-(6-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one 
• 929268-74-6 1-[3-(4'-fluorobiphenyl-2-yl)propanoyl]-4-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]piperazine 
• 385844-27-9 1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine 
• 838819-92-4 3-biphenyl-2-yl-1-[4-[2-(4-fluorophenyl)-2-(1-isopropylpiperidin-4-yl)acetyl]piperazin-1-yl]propane-1-one 
• 552885-78-6 benzyl 4-[[1-(tert-butoxycarbonyl)piperidin-4-yl](4-fluorophenyl)acetyl]piperazine-1-carboxylate 

Relevant articles and documents

Novel piperazines: Potent melanocortin-4 receptor antagonists with anxiolytic-like activity

In the present study, we found that a novel piperazine compound, 11a, showed a moderate affinity (IC50 = 333 nM) for the MC4 receptor. We developed the new type of piperazine compounds and found that mono-piperazine 11b exhibited a high-affinity (IC50 = 40.3 nM) for the MC4 receptor. We also found that a series of biphenyl analogues exhibited a high-affinity for the receptor, and in particular, compound 11j exhibited the highest affinity for the MC4 receptor with an IC50 value of 14.5 nM. Furthermore, some of these compounds, when administered orally, significantly reversed the stress-induced anxiety-like behavior in rats. In this paper, we report the synthesis, structure-activity relationships, and oral activity of the novel mono-piperazines as MC4 receptor antagonists.

Remedial agent for anxiety neurosis or depression and piperazine derivative

There are provided a therapeutic preparation for anxiety neurosis or depression which comprises a MC4 receptor antagonist as an effective ingredient; and a piperazine derivative represented by Formula [1]: [wherein Ar1 is a phenyl gr