N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(1-methylazetidin-3-yl)benzamide

Base Information

Chemical Name:N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(1-methylazetidin-3-yl)benzamide
CAS No.:1403591-10-5
Molecular Formula:C₂₇H₃₈N₄O₃
Molecular Weight:466.624
Hs Code.:

Synonyms:N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(1-methylazetidin-3-yl)benzamide

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Chemical Property of N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(1-methylazetidin-3-yl)benzamide

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Technology Process of N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(1-methylazetidin-3-yl)benzamide

There total 7 articles about N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(1-methylazetidin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403597-90-9
C₁₉H₂₈N₂O₃

: 1403591-10-5
N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(1-methylazetidin-3-yl)benzamide

Guidance literature:: C₁₉H₂₈N₂O₃; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; In N,N-dimethyl-formamide; for 21h;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403591-10-5
N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(1-methylazetidin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

3.2: 64 h

4.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

4.2: 22 h / 20 °C

5.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / Inert atmosphere

5.2: 16 h / 80 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.2: pH 7 - 8

7.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

7.2: 16 h / 20 °C

7.3: pH 8

8.1: sodium hydroxide / tetrahydrofuran; methanol / 16 h / 50 °C

8.2: pH 4

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

9.2: 21 h

With chloro-trimethyl-silane; iron; sodium carbonate; ammonium chloride; acetic acid; ethylene dibromide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1403257-79-3
2-methyl-3-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester

: 1403591-10-5
N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-(1-methylazetidin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / Inert atmosphere

1.2: 16 h / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.2: pH 7 - 8

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

3.2: 16 h / 20 °C

3.3: pH 8

4.1: sodium hydroxide / tetrahydrofuran; methanol / 16 h / 50 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 21 h

With chloro-trimethyl-silane; acetic acid; ethylene dibromide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; zinc; In tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE; 1,2-dichloro-ethane; N,N-dimethyl-formamide;