dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester

Base Information

• Chemical Name: dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester
• CAS No.: 845439-02-3
• Molecular Formula: C₂₈H₃₂N₂O₄S
• Molecular Weight: 492.639

Synonyms:dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester

Chemical Property of dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester

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Technology Process of dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester

There total 5 articles about dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N,N-Dimethylthiocarbamoyl chloride (16420-13-6) + 4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide (845438-93-9) → dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester (845439-02-3)

Guidance literature:

With dmap; sodium hydride;

DOI:10.1021/ol047741f

Reference yield:

benzyl bromide (100-39-0) → dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester (845439-02-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: CuSO₄; NaOH

1.2: 100 percent / Cs₂CO₃

2.1: 90 percent / Me₃Al / 80 °C

3.1: 75 percent / NaH; DMAP

With dmap; sodium hydroxide; trimethylaluminum; sodium hydride; copper(II) sulfate;

DOI:10.1021/ol047741f

Reference yield:

2-bromo-5-methoxy-benzoic acid (22921-68-2) → dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester (845439-02-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: CuSO₄; NaOH

1.2: 100 percent / Cs₂CO₃

2.1: 90 percent / Me₃Al / 80 °C

3.1: 75 percent / NaH; DMAP

With dmap; sodium hydroxide; trimethylaluminum; sodium hydride; copper(II) sulfate;

DOI:10.1021/ol047741f

upstream raw materials:

N,N-Dimethylthiocarbamoyl chloride

4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide

benzyl bromide

2-bromo-5-methoxy-benzoic acid

Downstream raw materials:

1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

7-benzyloxy-2-methoxy-9-thia-phenanthren-10-one

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