4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide

Base Information

• Chemical Name: 4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide
• CAS No.: 845438-93-9
• Molecular Formula: C₂₅H₂₇NO₄
• Molecular Weight: 405.494

Synonyms:4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide

Chemical Property of 4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide

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Technology Process of 4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide

There total 4 articles about 4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diethyl amine hydrochloride (660-68-4) + 3-(Benzyloxy)-8-methoxy-6H-benzo[c]chromen-6-one (845438-83-7) → 4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide (845438-93-9)

Guidance literature:

With trimethylaluminum; at 80 ℃;

DOI:10.1021/ol047741f

Reference yield:

benzyl bromide (100-39-0) → 4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide (845438-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CuSO₄; NaOH

1.2: 100 percent / Cs₂CO₃

2.1: 90 percent / Me₃Al / 80 °C

With sodium hydroxide; trimethylaluminum; copper(II) sulfate;

DOI:10.1021/ol047741f

Reference yield:

2-bromo-5-methoxy-benzoic acid (22921-68-2) → 4'-benzyloxy-2'-hydroxy-4-methoxy-biphenyl-2-carboxylic acid diethylamide (845438-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CuSO₄; NaOH

1.2: 100 percent / Cs₂CO₃

2.1: 90 percent / Me₃Al / 80 °C

With sodium hydroxide; trimethylaluminum; copper(II) sulfate;

DOI:10.1021/ol047741f

upstream raw materials:

diethyl amine hydrochloride

3-(Benzyloxy)-8-methoxy-6H-benzo[c]chromen-6-one

benzyl bromide

2-bromo-5-methoxy-benzoic acid

Downstream raw materials:

dimethyl-thiocarbamic acid O-(4-benzyloxy-2'-diethylcarbamoyl-4'-methoxy-biphenyl-2-yl) ester

1-[2-(4-{[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-triethylsilanyloxy-methyl}-phenoxy)-ethyl]-pyrrolidine

[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

[2-(tert-butyl-dimethyl-silanyloxy)-7-triisopropylsilanyloxy-10H-9-thia-phenanthren-10-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-methanol

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