(3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid

Base Information

Chemical Name:(3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid
CAS No.:1345822-99-2
Molecular Formula:C₁₈H₁₈F₃NO₂
Molecular Weight:337.342
Hs Code.:

Synonyms:(3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid

Suppliers and Price of (3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid

Chemical Property:

Boiling Point:440.7±45.0 °C(Predicted)
Density:1.267±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid

There total 6 articles about (3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

: 1345822-98-1
tert-butyl (3R)-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)butanoate maleate

: 1345822-99-2
(3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid

Guidance literature:: tert-butyl (3R)-3-[[(1R)-1-phenylethyl]amino]-4-(2,4,5-trifluorophenyl)butanoate maleate; With sulfuric acid; water; at 70 ℃; for 2h;

With sodium hydroxide; In water; pH=4;

With ammonia; In water; pH=7;

Reference yield:

: methyl (3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoate

: 1345822-99-2
(3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 10 - 15 ℃;

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1345822-99-2
(3R)-3-[(1R)-1-phenylethylamino]-4-(2,4,5-trifluorophenyl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / tert-butyl alcohol / 8 h / 30 - 82 °C

2.1: hydrogen / platinum on carbon / isopropyl alcohol / 35 °C / 2942.29 Torr

2.2: 1 h / Reflux

3.1: water; sulfuric acid / 2 h / 70 °C

3.2: pH 4

3.3: pH 7

With sulfuric acid; water; hydrogen; acetic acid; platinum on carbon; In isopropyl alcohol; tert-butyl alcohol;