tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate

Base Information

Chemical Name:tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate
CAS No.:1355159-06-6
Molecular Formula:C₂₁H₃₄N₂O₃Si
Molecular Weight:390.598
Hs Code.:

Synonyms:tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate

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Chemical Property of tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate

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Technology Process of tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate

There total 4 articles about tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355159-05-5
tert-butyl 2-(1-(4-cyanophenyl)-2-hydroxyethylamino)acetate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1355159-06-6
tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 20099-89-2
4-Cyanophenacyl bromide

: 1355159-06-6
tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium formate / methanol / 15 h / 20 °C / Reflux

2.1: dichloromethane; methanol / 1 h / 20 °C

2.2: 18 h

3.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

With 1H-imidazole; sodium formate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1443-80-7
4-cyanophenyl methyl ketone

: 1355159-06-6
tert-butyl 2-(2-(tert-butyldimethylsilyloxy)-1-(4-cyanophenyl)ethylamino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile; water / 18 h / Reflux

2.1: dichloromethane; methanol / 1 h / 20 °C

2.2: 18 h

3.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

With 1H-imidazole; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;