tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-methylpiperidin-4-ylcarbamate

Base Information

• Chemical Name: tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-methylpiperidin-4-ylcarbamate
• CAS No.: 1464154-49-1
• Molecular Formula: C₃₁H₃₂N₆O₃
• Molecular Weight: 536.633
• Mol file: 1464154-49-1.mol

Synonyms:tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-methylpiperidin-4-ylcarbamate

Chemical Property of tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-methylpiperidin-4-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-methylpiperidin-4-ylcarbamate

There total 4 articles about tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-methylpiperidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-butoxycarbonylamino-4-methylpiperidine (163271-08-7) + 4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoic acid (1464154-43-5) → tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-methylpiperidin-4-ylcarbamate (1464154-49-1)

Guidance literature:

With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

4-(6-chloroimidazo[1,2-b]pyridazin-3-yl)benzonitrile (1082604-63-4) → tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-methylpiperidin-4-ylcarbamate (1464154-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 90 °C

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; HATU; In water; N,N-dimethyl-formamide;

Reference yield:

6-chloro-3-iodo-imidazo[1,2-b]pyridazine (923595-49-7) → tert-butyl 1-(4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)-4-methylpiperidin-4-ylcarbamate (1464154-49-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 90 °C

3: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; HATU; In water; N,N-dimethyl-formamide;

upstream raw materials:

4-(6-chloroimidazo[1,2-b]pyridazin-3-yl)benzonitrile

6-chloro-3-iodo-imidazo[1,2-b]pyridazine

4-tert-butoxycarbonylamino-4-methylpiperidine

4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoic acid

Downstream raw materials:

4-(6-(4-(4-amino-4-mcthylpiperidine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile