2'-bromo-dehydrodesoxypodophyllotoxin

Base Information

• Chemical Name: 2'-bromo-dehydrodesoxypodophyllotoxin
• CAS No.: 60073-37-2
• Molecular Formula: C₂₂H₁₇BrO₇
• Molecular Weight: 473.277
• Mol file: 60073-37-2.mol

Synonyms:2'-bromo-dehydrodesoxypodophyllotoxin

Chemical Property of 2'-bromo-dehydrodesoxypodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-bromo-dehydrodesoxypodophyllotoxin

There total 10 articles about 2'-bromo-dehydrodesoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.5%

rac-(7'β,8α,8'percentb)-3',4',5'-trimethoxy-4,5-methylenedioxy-2,7'-cyclolignan-9',9-olide (477-51-0,6258-33-9,17187-81-4,17301-90-5,19186-35-7,24150-39-8,31892-96-3,55568-81-5,64550-41-0,69222-20-4,75171-57-2,83023-41-0,100348-38-7) → 2'-bromo-dehydrodesoxypodophyllotoxin (60073-37-2) + 5-(2,6-Dibromo-3,4,5-trimethoxy-phenyl)-8H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one (139219-12-8)

Guidance literature:

With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; dichloromethane; for 20h; Heating;

Reference yield:

2’-bromo-2α-chloropodophyllotoxin (1562422-36-9) + acetic acid (64-19-7,77671-22-8) → 2'-bromo-dehydrodesoxypodophyllotoxin (60073-37-2) + C24H22BrClO9 (1562421-66-2)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -18 - 20 ℃;

Reference yield:

2′-bromodeoxypicropodophyllotoxin → 2'-bromo-dehydrodesoxypodophyllotoxin (60073-37-2)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 70h; Heating;

DOI:10.1002/ardp.19933260709

upstream raw materials:

methanol

rac-(7'β,8α,8'percentb)-3',4',5'-trimethoxy-4,5-methylenedioxy-2,7'-cyclolignan-9',9-olide

yatein

deoxypicropodophyllin

Refernces

• 1、 San Feliciano,Medarde,Pelaez Lamamie De Clairac,Lopez,Puebla,Gravalos,Lazaro,De Quesada. "Synthesis and biological activity of bromolignans and cyclolignans". . p. 421 - 426. Retrieved 2007/10/02.