1562421-66-2

Basic information

• Product Name: C₂₄H₂₂BrClO₉
• Synonyms: C₂₄H₂₂BrClO₉
• CAS NO: 1562421-66-2
• Molecular Weight: 569.79
• Mol File: 1562421-66-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₂BrClO₉(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₂BrClO₉(1562421-66-2)
• EPA Substance Registry System: C₂₄H₂₂BrClO₉(1562421-66-2)

Safety Data

• Hazardous Substances Data: 1562421-66-2(Hazardous Substances Data)

Upstream product

• 1562422-36-9 2’-bromo-2α-chloropodophyllotoxin 
• 64-19-7 acetic acid 
• 518-28-5 podofilox 
• 40456-15-3 2′-bromopodophyllotoxin 
• 1562422-25-6 C₂₇H₂₉BrO₉ 

Relevant articles and documents

4 α-acyloxy -2 the [...] (2 the [...], the 6 [...] ), 2 α-halogenated podophyllotoxin derivatives, and their preparation and use

The invention discloses a series of new 4alpha-acyloxy-2'(2',6'),2alpha-polyhalogenated podophyllotoxin derivatives and a preparation method thereof. The chemical general formula of the series of 4alpha-acyloxy-2'(2',6'),2alpha-polyhalogenated podophyllot

Stereoselective synthesis of 2α-chloropicropodophyllotoxins and insecticidal activity of their esters against oriental armyworm, mythimna separata walker

As part of ongoing efforts to discover new natural-product-based insecticidal agents, in the present study, an efficient method for the stereoselective α-chlorination at the C-2 position of 2′(2′, 6′)-(di)halogenopodophyllotoxin derivatives was first developed. Subsequently, a series of novel esters of 2α-chloro-2′(2′, 6′)-(di)halogenopicropodophyllotoxin with modified C, D, and E rings of podophyllotoxin were smoothly obtained. Finally, all of the title compounds were tested against the pre-third-instar larvae of oriental armyworm (Mythimna separata Walker) at 1 mg/mL. It was found that besides their 2′-halogen-substituted E ring, the stereoselective α-chlorination at the C-2 position of 2′(2′,6′)-(di)halogenopodophyllotoxins was also related to the chlorination reagents. Especially 2α-chloro- 4α-(benzoyl)oxy-2′-chloropicropodophyllotoxin (6e) and 2α-chloro-4α-(2-chlorophenylacyl)oxy-2′- bromopicropodophyllotoxin (8f) showed the most potent insecticidal activities, with final mortality rates of >60%. For 4α-(alkylacyl)oxy derivatives of 2α-chloro-2′(2′,6′)-(di)halogenopicropodophyllotoxin, the effect of the length of their side chain at the C-4 position of podophyllotoxin skeleton on the insecticidal activity was not very obvious. For 4α-(arylacyl)oxy derivatives of 2α-chloro-2′-chloro/ bromopicropodophyllotoxin, an electronic effect of the substituents on their phenyl ring at the C-4 position of podophyllotoxin skeleton on the insecticidal activity was observed.