N-(tert-butyldimethylsilyloxy)-2-[N-isopropoxy(4-methoxyphenyl)sulfonamido]-3-methylbutanamide

Base Information

Chemical Name:N-(tert-butyldimethylsilyloxy)-2-[N-isopropoxy(4-methoxyphenyl)sulfonamido]-3-methylbutanamide
CAS No.:929224-98-6
Molecular Formula:C₂₁H₃₈N₂O₆SSi
Molecular Weight:474.694
Hs Code.:

Synonyms:N-(tert-butyldimethylsilyloxy)-2-[N-isopropoxy(4-methoxyphenyl)sulfonamido]-3-methylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(tert-butyldimethylsilyloxy)-2-[N-isopropoxy(4-methoxyphenyl)sulfonamido]-3-methylbutanamide

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Technology Process of N-(tert-butyldimethylsilyloxy)-2-[N-isopropoxy(4-methoxyphenyl)sulfonamido]-3-methylbutanamide

There total 4 articles about N-(tert-butyldimethylsilyloxy)-2-[N-isopropoxy(4-methoxyphenyl)sulfonamido]-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 929224-92-0
2-{isopropoxy[(4-methoxyphenyl)sulfonyl]amino}-3-methylbutanoic acid

: 41879-39-4
O-(tert-butyldimethylsilanyl)hydroxylamine

: 929224-98-6
N-(tert-butyldimethylsilyloxy)-2-[N-isopropoxy(4-methoxyphenyl)sulfonamido]-3-methylbutanamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2007.01.023

Reference yield:

: 929224-87-3
tert-butyl 2-{isopropoxy[(4-methoxyphenyl)sulfonyl]amino}-3-methylbutanoate

: 929224-98-6
N-(tert-butyldimethylsilyloxy)-2-[N-isopropoxy(4-methoxyphenyl)sulfonamido]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 0 °C

2: 87 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH₂Cl₂ / 20 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2007.01.023

Reference yield:

: 42877-95-2
(+/-)-tert-butyl 2-bromo-3-methylbutanoate

: 929224-98-6
N-(tert-butyldimethylsilyloxy)-2-[N-isopropoxy(4-methoxyphenyl)sulfonamido]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 25 percent / cesium carbonate; tetrabutylammonium hydrogensulfate / dimethylformamide / 72 h / 20 °C

2: 87 percent / trifluoroacetic acid / CH₂Cl₂ / 5 h / 0 °C

3: 87 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH₂Cl₂ / 20 h / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.01.023