(E)-2-cyano-3-(10-(4-(hexyloxy)phenyl)-3-(10-(4-(hexyloxy)-phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazin-7-yl)acrylic acid

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Chemical Name:(E)-2-cyano-3-(10-(4-(hexyloxy)phenyl)-3-(10-(4-(hexyloxy)-phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazin-7-yl)acrylic acid
CAS No.:1403613-90-0
Molecular Formula:C₅₂H₄₉N₃O₄S₂
Molecular Weight:844.111
Hs Code.:

Synonyms:(E)-2-cyano-3-(10-(4-(hexyloxy)phenyl)-3-(10-(4-(hexyloxy)-phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazin-7-yl)acrylic acid

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Chemical Property of (E)-2-cyano-3-(10-(4-(hexyloxy)phenyl)-3-(10-(4-(hexyloxy)-phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazin-7-yl)acrylic acid

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Technology Process of (E)-2-cyano-3-(10-(4-(hexyloxy)phenyl)-3-(10-(4-(hexyloxy)-phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazin-7-yl)acrylic acid

There total 3 articles about (E)-2-cyano-3-(10-(4-(hexyloxy)phenyl)-3-(10-(4-(hexyloxy)-phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazin-7-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1403613-85-3
10-(4-(hexyloxy)phenyl)-7-(10-(4-(hexyloxy)phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazine-3-carbaldehyde

: 372-09-8
cyanoacetic acid

: 1403613-90-0
(E)-2-cyano-3-(10-(4-(hexyloxy)phenyl)-3-(10-(4-(hexyloxy)-phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazin-7-yl)acrylic acid

Guidance literature:: With ammonium acetate; In acetic acid; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c2jm35556f

Reference yield:

: {10-[4-(hexyloxy)phenyl]-10H-phenothiazin-3-yl}boronic acid

: 1403613-90-0
(E)-2-cyano-3-(10-(4-(hexyloxy)phenyl)-3-(10-(4-(hexyloxy)-phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazin-7-yl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water; toluene / 12 h / 60 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 6 h / -78 °C / Inert atmosphere

3.1: ammonium acetate / acetic acid / 12 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; ammonium acetate; potassium carbonate; In tetrahydrofuran; hexane; water; acetic acid; toluene; 1.1: |Suzuki-Miyaura Coupling / 3.1: |Knoevenagel Condensation;
DOI:10.1039/c2jm35556f

Reference yield:

: C₃₀H₃₈BNO₃S

: 1403613-90-0
(E)-2-cyano-3-(10-(4-(hexyloxy)phenyl)-3-(10-(4-(hexyloxy)-phenyl)-10H-phenothiazin-7-yl)-10H-phenothiazin-7-yl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / tetrahydrofuran; hexane / 1 h / 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water; toluene / 12 h / 60 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 6 h / -78 °C / Inert atmosphere

4.1: ammonium acetate / acetic acid / 12 h / 100 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; ammonium acetate; water; potassium carbonate; In tetrahydrofuran; hexane; water; acetic acid; toluene; 2.1: |Suzuki-Miyaura Coupling / 4.1: |Knoevenagel Condensation;
DOI:10.1039/c2jm35556f