(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol

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Chemical Name:(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol
CAS No.:1262414-02-7
Molecular Formula:C₂₅H₃₃N₃O₅
Molecular Weight:455.554
Hs Code.:

Synonyms:(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol

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Chemical Property of (S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol

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Technology Process of (S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol

There total 11 articles about (S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1262414-02-7
(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / water / 34 - 70 °C

1.2: 20 °C

2.1: sulfuric acid / 24 h / Reflux

3.1: Pd(dppf) / tetrahydrofuran / 18 h / 85 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / 20 °C

5.2: 1 h / 20 °C

6.1: 1,4-dioxane / 18 h / 105 °C

7.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sulfuric acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 3.1: Negishi Coupling Reaction;

Reference yield:

: 42521-10-8
2-chloro-6-methoxyisonicotinic acid methyl ester

: 1262414-02-7
(S)-3-(2-ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: Pd(dppf) / tetrahydrofuran / 18 h / 85 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / 20 °C

3.2: 1 h / 20 °C

4.1: 1,4-dioxane / 18 h / 105 °C

5.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Pd(dppf); In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 1.1: Negishi Coupling Reaction;