4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine

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Chemical Name:4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine
CAS No.:1262414-03-8
Molecular Formula:C₂₈H₃₇N₃O₅
Molecular Weight:495.619
Hs Code.:

Synonyms:4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine

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Chemical Property of 4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine

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Technology Process of 4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine

There total 11 articles about 4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1262414-03-8
4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 34 - 70 °C

1.2: 20 °C

2.1: sulfuric acid / 24 h / Reflux

3.1: Pd(dppf) / tetrahydrofuran / 18 h / 85 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / 20 °C

5.2: 1 h / 20 °C

6.1: 1,4-dioxane / 18 h / 105 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sulfuric acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 3.1: Negishi Coupling Reaction;

Reference yield:

: 42521-10-8
2-chloro-6-methoxyisonicotinic acid methyl ester

: 1262414-03-8
4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Pd(dppf) / tetrahydrofuran / 18 h / 85 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 1 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / 20 °C

3.2: 1 h / 20 °C

4.1: 1,4-dioxane / 18 h / 105 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Pd(dppf); In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 1.1: Negishi Coupling Reaction;

Reference yield:

: 1122089-63-7
2-methoxy-6-(pentan-3-yl)isonicotinic acid

: 1150644-85-1
(R)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-N-hydroxy-5-methylbenzylhydrazine

: 1262414-03-8
4-{3-[4-((R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-5-methyl-phenyl]-[1,2,4]oxadiazol-5-yl}-2-(1-ethyl-propyl)-6-methoxy-pyridine

Guidance literature:: 2-methoxy-6-(pentan-3-yl)isonicotinic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(R)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-N-hydroxy-5-methylbenzylhydrazine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;