2-bromo-6-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-4-methoxy-benzamide

Base Information

Chemical Name:2-bromo-6-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-4-methoxy-benzamide
CAS No.:460348-05-4
Molecular Formula:C₁₈H₃₀BrNO₃Si
Molecular Weight:416.431
Hs Code.:

2-bromo-6-(<i>tert</i>-butyl-dimethyl-silanyloxy)-<i>N</i>,<i>N</i>-diethyl-4-methoxy-benzamide

Synonyms:2-bromo-6-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-4-methoxy-benzamide

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Chemical Property of 2-bromo-6-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-4-methoxy-benzamide

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Technology Process of 2-bromo-6-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-4-methoxy-benzamide

There total 4 articles about 2-bromo-6-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-4-methoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 460348-03-2
2-((tert-butyldimethylsilyl)oxy)-N,N-diethyl-4-methoxybenzamide

: 460348-05-4
2-bromo-6-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-4-methoxy-benzamide

Guidance literature:: 2-((tert-butyldimethylsilyl)oxy)-N,N-diethyl-4-methoxybenzamide; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.166667h;

With bromine; In diethyl ether; pentane;
DOI:10.1016/S0040-4039(02)00870-5

Reference yield:

: 2237-36-7
4-methoxysalicylic acid

: 460348-05-4
2-bromo-6-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: iPr₂NEt / dimethylformamide / 2 h / 20 °C

1.2: oxalyl chloride; DMF / CH₂Cl₂ / -10 - 20 °C

1.3: 48 percent / CH₂Cl₂ / 1 h / 20 °C

2.1: t-BuLi / pentane; diethyl ether / 0.17 h / -78 °C

2.2: 75 percent / Br₂ / pentane; diethyl ether

With tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; In diethyl ether; N,N-dimethyl-formamide; pentane;
DOI:10.1016/S0040-4039(02)00870-5

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 460348-05-4
2-bromo-6-(tert-butyl-dimethyl-silanyloxy)-N,N-diethyl-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: iPr₂NEt / dimethylformamide / 2 h / 20 °C

1.2: oxalyl chloride; DMF / CH₂Cl₂ / -10 - 20 °C

1.3: 48 percent / CH₂Cl₂ / 1 h / 20 °C

2.1: t-BuLi / pentane; diethyl ether / 0.17 h / -78 °C

2.2: 75 percent / Br₂ / pentane; diethyl ether

With tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; In diethyl ether; N,N-dimethyl-formamide; pentane;
DOI:10.1016/S0040-4039(02)00870-5