(R,R)-N-(1-benzyl-1,2,3-triazole-4-ylmethyl)-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane

Base Information

Chemical Name:(R,R)-N-(1-benzyl-1,2,3-triazole-4-ylmethyl)-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane
CAS No.:1402063-30-2
Molecular Formula:C₂₁H₃₁N₅O₂
Molecular Weight:385.509
Hs Code.:

Synonyms:(R,R)-N-(1-benzyl-1,2,3-triazole-4-ylmethyl)-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane

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Chemical Property of (R,R)-N-(1-benzyl-1,2,3-triazole-4-ylmethyl)-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane

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Technology Process of (R,R)-N-(1-benzyl-1,2,3-triazole-4-ylmethyl)-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane

There total 3 articles about (R,R)-N-(1-benzyl-1,2,3-triazole-4-ylmethyl)-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1229407-35-5
(R,R)-N-propargyl-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane

: 622-79-7
benzyl azide

: 1402063-30-2
(R,R)-N-(1-benzyl-1,2,3-triazole-4-ylmethyl)-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane

Guidance literature:: With copper diacetate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 - 22 ℃; for 72h; Inert atmosphere;
DOI:10.1021/ol302354z DOI:10.1021/ol302354z

Reference yield:

: 146504-07-6
tert-butyl ((1R,2R)-2-aminocyclohexyl)carbamate

: 1402063-30-2
(R,R)-N-(1-benzyl-1,2,3-triazole-4-ylmethyl)-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile; toluene / 24 h / 80 °C / Inert atmosphere

2: copper diacetate; sodium L-ascorbate / tert-butyl alcohol; water / 72 h / 20 - 22 °C / Inert atmosphere

With copper diacetate; potassium carbonate; sodium L-ascorbate; In water; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ol302354z DOI:10.1021/ol302354z

Reference yield:

: 100-39-0
benzyl bromide

: 1402063-30-2
(R,R)-N-(1-benzyl-1,2,3-triazole-4-ylmethyl)-N’-tert-butoxycarbonyl-1,2-diaminocyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 2 h / Inert atmosphere

2: copper diacetate; sodium L-ascorbate / tert-butyl alcohol; water / 72 h / 20 - 22 °C / Inert atmosphere

With sodium azide; copper diacetate; sodium L-ascorbate; In water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1021/ol302354z DOI:10.1021/ol302354z