N₂-isobutyryl-2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

Base Information

• Chemical Name: N₂-isobutyryl-2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite
• CAS No.: 1360744-45-1
• Molecular Formula: C₅₈H₇₉N₁₀O₁₃P
• Molecular Weight: 1155.3

Synonyms:N₂-isobutyryl-2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

Chemical Property of N₂-isobutyryl-2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

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Technology Process of N₂-isobutyryl-2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite

There total 1 articles about N₂-isobutyryl-2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-O-(3-(N,N'-di-tert-butoxycarbonylguanidino)propyl)-3',5'-(O-di-tert-butylsilanediyl)guanosine (1360744-39-3) + 4,4'-dimethoxytrityl chloride (40615-36-9) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + isobutyryl chloride (79-30-1) → N2-isobutyryl-2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite (1360744-45-1) + N2-isobutyryl-2'-O-(N,N'-di-Boc-N'-isobutyryl-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-guanosine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite (1360744-46-2)

Guidance literature:

2'-O-(3-(N,N'-di-tert-butoxycarbonylguanidino)propyl)-3',5'-(O-di-tert-butylsilanediyl)guanosine; isobutyryl chloride; With pyridine; at 0 - 20 ℃; for 2h;

With triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

4,4'-dimethoxytrityl chloride; N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite; Further stages;

DOI:10.1016/j.bmc.2011.12.024

upstream raw materials:

2'-O-(3-(N,N'-di-tert-butoxycarbonylguanidino)propyl)-3',5'-(O-di-tert-butylsilanediyl)guanosine

4,4'-dimethoxytrityl chloride

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

isobutyryl chloride

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