5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide
CAS No.:1333244-39-5
Molecular Formula:C₂₃H₁₈BrFN₂O₄S
Molecular Weight:517.375
Hs Code.:

Synonyms:5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide

There total 11 articles about 5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1333244-38-4
5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid

: 593-51-1
methylamine hydrochloride

: 1333244-39-5
5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

methylamine hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield:

: 220801-66-1
5-bromo-2-hydroxylphenylacetic acid methyl ester

: 1333244-39-5
5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1H-imidazole / dichloromethane / 15 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 - 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

4.1: hydrogenchloride / water; acetone / 1 h / Reflux

5.1: nitric acid / chloroform / 4 h / 20 °C

6.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux

7.1: pyridine / dichloromethane / 15 h / 0 - 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere

9.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / 100 °C

9.2: pH 3

10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

10.2: 15 h / 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; nitric acid; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1333225-30-1
methyl 2-(5-bromo-2-hydroxyphenyl)-3-(4-fluorophenyl)-3-oxopropanoate

: 1333244-39-5
5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylphenylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / water; acetone / 1 h / Reflux

2.1: nitric acid / chloroform / 4 h / 20 °C

3.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux

4.1: pyridine / dichloromethane / 15 h / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / 100 °C

6.2: pH 3

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

7.2: 15 h / 20 °C

With pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; nitric acid; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;