5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid

Base Information

Chemical Name:5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid
CAS No.:1333244-38-4
Molecular Formula:C₂₂H₁₅BrFNO₅S
Molecular Weight:504.333
Hs Code.:

Synonyms:5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid

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Chemical Property of 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid

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Technology Process of 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid

There total 10 articles about 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333244-37-3
methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate

: 1333244-38-4
5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid

Guidance literature:: methyl 5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido)benzofuran-3-carboxylate; With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 100 ℃; for 2h;

With hydrogenchloride; In water; pH=3;

Reference yield:

: 220801-66-1
5-bromo-2-hydroxylphenylacetic acid methyl ester

: 1333244-38-4
5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1H-imidazole / dichloromethane / 15 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 - 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

4.1: hydrogenchloride / water; acetone / 1 h / Reflux

5.1: nitric acid / chloroform / 4 h / 20 °C

6.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux

7.1: pyridine / dichloromethane / 15 h / 0 - 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere

9.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / 100 °C

9.2: pH 3

With pyridine; 1H-imidazole; hydrogenchloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; nitric acid; iron; potassium carbonate; ammonium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1333225-30-1
methyl 2-(5-bromo-2-hydroxyphenyl)-3-(4-fluorophenyl)-3-oxopropanoate

: 1333244-38-4
5-bromo-2-(4-fluorophenyl)-6-(N-methylphenylsulfonamido) benzofuran-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water; acetone / 1 h / Reflux

2.1: nitric acid / chloroform / 4 h / 20 °C

3.1: ammonium chloride; iron / water; tetrahydrofuran; methanol / 3 h / Reflux

4.1: pyridine / dichloromethane / 15 h / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / 100 °C

6.2: pH 3

With pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; nitric acid; iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;