1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester)

Base Information

• Chemical Name: 1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester)
• CAS No.: 1049020-10-1
• Molecular Formula: C₅₂H₈₀N₄O₁₂
• Molecular Weight: 953.227
• Mol file: 1049020-10-1.mol

Synonyms:1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester)

Chemical Property of 1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester)

There total 4 articles about 1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester (162148-48-3) + α-bromoglutaric acid 1-tert-butyl ester 5-benzyl ester (306776-74-9) → 1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester) (1049020-10-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1039/b805281f

Reference yield:

(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester (162148-48-3) + α-bromoglutaric acid 1-tert-butyl ester 5-benzyl ester (306776-74-9) → 1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester) (1049020-10-1) + 5-benzyl 1-tert-butyl 2-(4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanedioate

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

5-benzyloxy-2-bromo-5-oxopetanoic acid → 1,4,7,10-tetraazacyclododecane-1,7-bis(t-butyl acetate)-4,10-bis(glutaric acid 1-tert-butyl ester-5-benzyl ester) (1049020-10-1) + 5-benzyl 1-tert-butyl 2-(4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanedioate

Guidance literature:

Multi-step reaction with 2 steps

1: cyclohexene; boron trifluoride diethyl etherate / chloroform; N,N-dimethyl acetamide / 72 h / 20 °C

2: potassium carbonate / dichloromethane / 4 h / 20 °C

With boron trifluoride diethyl etherate; potassium carbonate; cyclohexene; In dichloromethane; chloroform; N,N-dimethyl acetamide;

upstream raw materials:

(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester

α-bromoglutaric acid 1-tert-butyl ester 5-benzyl ester

L-glutamic acid γ-benzyl ester