(2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid

Base Information

Chemical Name:(2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid
CAS No.:109292-79-7
Molecular Formula:C₂₃H₂₃ClO₆
Molecular Weight:430.885
Hs Code.:

Synonyms:(2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid

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Chemical Property of (2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid

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Technology Process of (2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid

There total 24 articles about (2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34098-18-5
5-chloro-3,4-dihydroxybenzaldehyde

: 109292-79-7
(2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: NaF / dimethylformamide

2: NaH / 1,2-dimethoxy-ethane

3: H₂ / Pd / C

4: NaOH

5: LDA

6: 1.) LDA / 2.) THF , -78 to 0 deg C

With sodium hydroxide; hydrogen; sodium hydride; sodium fluoride; lithium diisopropyl amide; palladium on activated charcoal; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00178a042

Reference yield:

: 34098-18-5
5-chloro-3,4-dihydroxybenzaldehyde

: 109292-79-7
(2R,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: NaF / dimethylformamide

2: NaH / 1,2-dimethoxy-ethane

3: H₂ / Pd / C

4: NaOH

5: LDA

6: 1.) LDA / 2.) THF , -78 to 0 deg C

With sodium hydroxide; hydrogen; sodium hydride; sodium fluoride; lithium diisopropyl amide; palladium on activated charcoal; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00178a042

Reference yield:

: 19463-48-0
5-chlorovanillin

: 109292-79-7
(2S,3S)-2-(7-Chloro-benzo[1,3]dioxol-5-ylmethyl)-3-hydroxy-3-isopropyl-5-(4-methoxy-phenyl)-pent-4-ynoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: BCl₃

2: NaF / dimethylformamide

3: NaH / 1,2-dimethoxy-ethane

4: H₂ / Pd / C

5: NaOH

6: LDA

7: 1.) LDA / 2.) THF , -78 to 0 deg C

With sodium hydroxide; hydrogen; boron trichloride; sodium hydride; sodium fluoride; lithium diisopropyl amide; palladium on activated charcoal; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00178a042