34098-18-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE is used as a key building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows for the development of new compounds with therapeutic and pesticidal properties.
Used in Skincare and Personal Care Products:
3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE is used as an antioxidant and antibacterial agent in the formulation of skincare and personal care products. Its ability to combat oxidative stress and inhibit bacterial growth contributes to the development of effective and safe products for skin health and hygiene.
Used in Medical and Healthcare Industries:
3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE is studied for its potential anti-inflammatory and anti-cancer properties. Its ability to modulate inflammatory responses and inhibit cancer cell growth makes it a promising candidate for the development of new therapeutic agents in the medical and healthcare industries.

InChI:InChI=1/C7H5ClO3/c8-5-1-4(3-9)2-6(10)7(5)11/h1-3,10-11H

Upstream product

• 19463-48-0 5-chlorovanillin 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 100-52-7 benzaldehyde 
• 54246-06-9 3-chloro-5-hydroxy-4-methoxybenzaldehyde 
• 621-59-0 isovanillin 
• 76681-74-8 C₂₃H₁₆O₈ 
• 121-33-5 vanillin 

Downstream Products

• 88525-51-3 7-chlorobenzo[d][1,3]dioxole-5-carbaldehyde 
• 33584-87-1 3-chloro-4,5-di(phenylmethoxy)benzaldehyde 
• 1027584-61-7 4-benzyloxy-3-chloro-5-methoxymethoxy-benzaldehyde 
• 232945-35-6 3-tert-butoxycarbonylamino-3-(3-chloro-4-hydroxy-5-methoxymethoxy-phenyl)-propionic acid tert-butyl ester 
• 232945-31-2 (S)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-3-(3-chloro-4-hydroxy-5-methoxymethoxy-phenyl)-propionic acid tert-butyl ester 
• 1027564-53-9 (S)-3-(4-Benzyloxy-3-chloro-5-methoxymethoxy-phenyl)-3-[benzyl-((R)-1-phenyl-ethyl)-amino]-propionic acid tert-butyl ester 
• 232945-34-5 3-[benzyl-(1-phenyl-ethyl)-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-chloro-5-methoxymethoxy-phenyl]-propionic acid tert-butyl ester 
• 112636-66-5 3-chloro-4,5-dipropargyloxybenzaldehyde 
• 1365030-66-5 3-(tert-butyldimethylsilyloxy)-5-chloro-4-methoxybenzaldehyde 
• 1365030-67-6 3-(tert-butyldimethylsilyloxy)-5-chloro-4-methoxyphenyl formate 
• 1365030-68-7 3-(tert-Butyldimethylsilyloxy)-5-chloro-4-methoxyphenol 
• 1365030-69-8 2-bromo-5-(tert-butyldimethylsilyloxy)-3-chloro-4-methoxyphenol 
• 1365030-46-1 4-bromo-5-chloro-6-methoxybenzene-1,3-diol 
• 682744-11-2 3,4-bis(tert-butyldimethylsilyloxy)-5-chlorobenzaldehyde 

Relevant academic research and scientific papers

IMIDAXOPYROLONE COMPOUND AND APPLICATION THEREOF

Disclosed is a novel class of MDM2-p53 inhibitor compounds having an imidaxopyrolone structure, and specifically disclosed are compounds represented by formulas (I-1) and (I-2) and pharmaceutically acceptable salts thereof. (I-1), (I-2)

Synthetic Studies toward Bazzanin K: Regioselective and Chemoselective Three-Component Suzuki Coupling

The terphenyl substructure of the chiral cyclophane natural product bazzanin K was constructed. The key step involved sequential Suzuki couplings of a nonsymmetric dibromobenzene, which can be performed as a two-step process or as a one-pot three-componen

2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF

Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors

The development of inhibitors blocking STAT3 transcriptional activity is a promising therapeutic approach against cancer and inflammatory diseases. In this context, the selectivity of inhibitors against the STAT1 transcription factor is crucial as STAT3 and STAT1 play opposite roles in the apoptosis of tumor cells and polarization of the immune response. A structure-based virtual screening followed by a luciferase-containing promoter assay on STAT3 and STAT1 signaling were used to identify a selective STAT3 inhibitor. An important role of the aminotetrazole group in modulating STAT3 and STAT1 inhibitory activities has been established. Optimization of the hit compound leads to 23. This compound inhibits growth and survival of cells with STAT3 signaling pathway while displaying a minimal effect on STAT1 signaling. Moreover, it prevents lymphocyte T polarization into Th17 and Treg without affecting their differentiation into Th1 lymphocyte.

Synthesis and antitumor activity of feruloyl and caffeoyl derivatives This paper is dedicated to Prof. Wei-xiao Hu for his lifelong commitment to mentoring graduate students

We developed two efficient protocols for the synthesis of feruloyl and caffeoyl derivatives from commercial vanillin and veratraldehyde. Pharmacological activities were assessed against a panel of human cancer cell lines in vitro. Most synthesized compounds demonstrated attractive cytotoxicity. Several new compounds demonstrated significant antiproliferative and cytotoxic activities against HeLa and Bewo tumor cell lines. In particular, 5-nitro caffeic adamantyl ester showed broad spectrum of tumor inhibition in 10 cell lines, and reduced tumor weight by 36.7% in vivo when administered at a dose of 40 mg kg-1.

SUBSTITUTED PYRAZOLE-CONTAINING COMPOUNDS AND THEIR USE AS PESTICIDES

The present invention relates to substituted pyrazole-containingcompounds of formula (I), and the stereoisomers and salts thereof, wherein the substituents are as defined in the description. The present invention further relates to a method for combating or controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites, to a process for the preparation of a composition for treating infested or infected animals and/or for protecting animals against infestation or infection by parasites, and to a compound according to the invention for use as a medicament.

Synthesis of a new carbon-11-labeled sulfamate derivative as a potential PET tracer for imaging of breast cancer aromatase and steroid sulfatase expression

A carbon-11-labeled sulfamate derivative was designed and synthesized as a new potential positron-emission-tomography dual aromatase-steroid sulfatase inhibitor radiotracer for imaging of aromatase and steroid sulfatase expression in breast cancer. The ta

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

PROKINETICIN RECEPTOR ANTAGONISTS AND USES THEREOF

Contemplated compounds, compositions, and methods of prokineticin antagonists are presented where a prokineticin antagonist is used in the treatment and prevention of various conditions and disorders, and especially type II diabetes.