1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]phenyl]urea

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Chemical Name:1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]phenyl]urea
CAS No.:1402581-67-2
Molecular Formula:C₂₁H₂₀ClF₃N₄O₄
Molecular Weight:484.862
Hs Code.:

Synonyms:1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]phenyl]urea

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Chemical Property of 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]phenyl]urea

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Technology Process of 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]phenyl]urea

There total 7 articles about 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1419602-48-4
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

: 1402585-98-1
phenyl 4-(1,2,3-trihydroxypropan-2-yl)phenylcarbamate

: 1402581-67-2
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]phenyl]urea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 23 ℃; for 16h;

Reference yield:

: 2945-08-6
methyl (4-nitrophenyl)acetate

: 1402581-67-2
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1: acetic anhydride / dimethyl sulfoxide / 2 h / 23 °C

2: diisobutylaluminium hydride / diethyl ether; toluene / 2 h / -78 - 0 °C

3: 4-methylmorpholine N-oxide; water; osmium(VIII) oxide / acetone; 2-methyl-propan-1-ol / 1 h / 0 - 23 °C

4: hydrogen; palladium 10% on activated carbon / ethanol / 1 h / 23 °C

5: sodium hydrogencarbonate / water; tetrahydrofuran / 0.5 h / 0 - 23 °C

6: triethylamine / tetrahydrofuran / 16 h / 23 °C

With osmium(VIII) oxide; palladium 10% on activated carbon; water; hydrogen; acetic anhydride; diisobutylaluminium hydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; acetone; toluene;

Reference yield:

: 15121-86-5
2-(4-nitrophenyl)prop-2-en-1-ol

: 1402581-67-2
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methylmorpholine N-oxide; water; osmium(VIII) oxide / acetone; 2-methyl-propan-1-ol / 1 h / 0 - 23 °C

2: hydrogen; palladium 10% on activated carbon / ethanol / 1 h / 23 °C

3: sodium hydrogencarbonate / water; tetrahydrofuran / 0.5 h / 0 - 23 °C

4: triethylamine / tetrahydrofuran / 16 h / 23 °C

With osmium(VIII) oxide; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; ethanol; 2-methyl-propan-1-ol; water; acetone;