(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

Base Information

Chemical Name:(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride
CAS No.:1419602-48-4
Molecular Formula:C₁₁H₉ClF₃N₃*ClH
Molecular Weight:312.122
Hs Code.:

Synonyms:(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

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Chemical Property of (1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

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Technology Process of (1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

There total 7 articles about (1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1254713-77-3
1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile

: 1419602-48-4
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

Guidance literature:: 1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 23 ℃; for 24h;

With hydrogenchloride; In diethyl ether; for 2h;

Reference yield:

: 108-42-9
3-chloro-aniline

: 1419602-48-4
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water / 0.17 h / -5 - 0 °C

1.2: 5 h / -5 - 0 °C

2.1: ethanol / 3 h / Reflux

3.1: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C

4.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 24 h / 0 - 23 °C

5.2: 2 h

With hydrogenchloride; dimethylsulfide borane complex; potassium iodide; isopentyl nitrite; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; water; acetonitrile;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1419602-48-4
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 3 h / Reflux

2.1: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 24 h / 0 - 23 °C

4.2: 2 h

With dimethylsulfide borane complex; potassium iodide; isopentyl nitrite; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; acetonitrile;