Technology Process of (1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride
There total 7 articles about (1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile;
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 0 - 23 ℃;
for 24h;
With
hydrogenchloride;
In
diethyl ether;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride / water / 0.17 h / -5 - 0 °C
1.2: 5 h / -5 - 0 °C
2.1: ethanol / 3 h / Reflux
3.1: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C
4.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C
5.1: dimethylsulfide borane complex / tetrahydrofuran / 24 h / 0 - 23 °C
5.2: 2 h
With
hydrogenchloride; dimethylsulfide borane complex; potassium iodide; isopentyl nitrite;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ethanol / 3 h / Reflux
2.1: potassium iodide; isopentyl nitrite / acetonitrile / 20 h / 0 - 1000 °C
3.1: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 24 h / 0 - 23 °C
4.2: 2 h
With
dimethylsulfide borane complex; potassium iodide; isopentyl nitrite;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; acetonitrile;
