3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-8-fluoro-2-methoxyquinoline

Base Information

Chemical Name:3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-8-fluoro-2-methoxyquinoline
CAS No.:1599529-37-9
Molecular Formula:C₂₀H₁₄BrClFN₃O
Molecular Weight:446.706
Hs Code.:

Synonyms:3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-8-fluoro-2-methoxyquinoline

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Chemical Property of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-8-fluoro-2-methoxyquinoline

Chemical Property:

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Technology Process of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-8-fluoro-2-methoxyquinoline

There total 4 articles about 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-8-fluoro-2-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1599529-36-8
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-fluoroquinoline

: 124-41-4
sodium methylate

: 1599529-37-9
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-8-fluoro-2-methoxyquinoline

: 1599529-38-0
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2,8-dimethoxyquinoline

Guidance literature:: In toluene; at 108 - 110 ℃; for 12h; Sealed tube;

Reference yield:

: 99662-34-7
4-(1H-pyrazol-1-yl)benzaldehyde

: 1599529-37-9
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-8-fluoro-2-methoxyquinoline

: 1599529-38-0
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2,8-dimethoxyquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline / ethanol / 0.67 h

2: sodium hydroxide; water / 48 h / 110 °C

3: trichlorophosphate / 3 h / 105 °C

4: toluene / 12 h / 108 - 110 °C / Sealed tube

With water; L-proline; sodium hydroxide; trichlorophosphate; In ethanol; toluene;

Reference yield:

: 1599528-96-7
5-(4-(1H-pyrazol-1-yl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 1599529-37-9
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-8-fluoro-2-methoxyquinoline

: 1599529-38-0
3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-4-chloro-2,8-dimethoxyquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / 48 h / 110 °C

2: trichlorophosphate / 3 h / 105 °C

3: toluene / 12 h / 108 - 110 °C / Sealed tube

With water; sodium hydroxide; trichlorophosphate; In toluene;