((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate

Base Information

Chemical Name:((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate
CAS No.:293751-33-4
Molecular Formula:C₃₂H₂₇N₅O₆
Molecular Weight:577.596
Hs Code.:

Synonyms:((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate

Suppliers and Price of ((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of ((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of ((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate

There total 10 articles about ((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 532-32-1
sodium benzoate

: 293751-32-3
((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methyl methanesulfonate

: 293751-33-4
((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate

Guidance literature:: In dimethyl sulfoxide; at 100 ℃; for 2h;
DOI:10.1016/j.bmcl.2014.04.050

Reference yield:

: 293751-18-5
1-(2-O-acetyl-3-O-benzyl-4-C-methanesulfonoxymethyl-5-O-methanesulfonyl-β-D-erythro-pentofuranosyl)-6-N-benzoyladenine

: 293751-33-4
((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 3.5 h / 20 °C

2: 88 percent / dimethylformamide / 7 h / 90 °C

With lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo010732p

Reference yield:

: 293751-03-8
1,2-di-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-D-erythro-pentofuranose

: 293751-33-4
((1R,3R,4R,7S)-3-(6-benzamido-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / 1 h / Heating

1.2: 68 percent / trimethylsilyl triflate / 1,2-dichloro-ethane / 29 h / Heating

2.1: 78 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 3.5 h / 20 °C

3.1: 88 percent / dimethylformamide / 7 h / 90 °C

With lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo010732p