(S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid

Base Information

Chemical Name:(S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid
CAS No.:420110-84-5
Molecular Formula:C₁₄H₁₇F₃N₂O₃
Molecular Weight:318.296
Hs Code.:

Synonyms:(S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid

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Technology Process of (S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid

There total 1 articles about (S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 420110-66-3
(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide

: 420110-84-5
(S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃;
DOI:10.1002/1099-0690(20022)2002:3<428::AID-EJOC428<3.0.CO;2-J

Reference yield: 70.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 420110-84-5
(S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid

: (S)-N-Benzyloxy-4,4,4-trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyramide

Guidance literature:: With TEA; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1002/1099-0690(20022)2002:3<428::AID-EJOC428<3.0.CO;2-J

Reference yield:

: 420110-84-5
(S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid

: (S)-4,4,4-Trifluoro-N-hydroxy-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / TEA; EDC*HCl; 1-hydroxybenzotriazole / dimethylformamide / 0 °C

2: 88 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

With TEA; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium dihydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1002/1099-0690(20022)2002:3<428::AID-EJOC428<3.0.CO;2-J