(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide

Base Information

Chemical Name:(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide
CAS No.:420110-66-3
Molecular Formula:C₂₄H₂₆F₃N₃O₄
Molecular Weight:477.483
Hs Code.:

Synonyms:(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide

Chemical Property:

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Hazard Codes:

MSDS Files:

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Technology Process of (S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide

There total 1 articles about (S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: H-Phe-NHMe trifluoroacetate

: 243121-08-6
(S)-4-benzyl-3-[(E)-4,4,4-trifluorobut-2-enoyl]oxazolidin-2-one

: 420110-66-3
(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide

: (S)-2-[(R)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide

Guidance literature:: With 2,4,6-trimethyl-pyridine; In dichloromethane; at 20 ℃;
DOI:10.1002/1099-0690(20022)2002:3<428::AID-EJOC428<3.0.CO;2-J

Reference yield: 85.0%

: 420110-66-3
(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide

: 420110-84-5
(S)-4,4,4-Trifluoro-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyric acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃;
DOI:10.1002/1099-0690(20022)2002:3<428::AID-EJOC428<3.0.CO;2-J

Reference yield:

: 420110-66-3
(S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-methyl-3-phenyl-propionamide

: (S)-4,4,4-Trifluoro-N-hydroxy-3-((S)-1-methylcarbamoyl-2-phenyl-ethylamino)-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / aq. H₂O₂; LiOH*H₂O / tetrahydrofuran / 0 °C

2: 70 percent / TEA; EDC*HCl; 1-hydroxybenzotriazole / dimethylformamide / 0 °C

3: 88 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

With lithium hydroxide; TEA; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium dihydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/1099-0690(20022)2002:3<428::AID-EJOC428<3.0.CO;2-J