diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate

Base Information

Chemical Name:diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate
CAS No.:1312919-72-4
Molecular Formula:C₃₀H₃₁FN₂O₇S
Molecular Weight:582.65
Hs Code.:

Synonyms:diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate

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Chemical Property of diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate

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Technology Process of diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate

There total 7 articles about diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1092117-57-1
C₁₈H₁₁ClFNO₃S

: 58660-74-5,58660-75-6,58660-76-7,58660-77-8
diethyl 4-aminocyclohexane-1,3-dicarboxylate

: 1312919-72-4
diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

: 63579-89-5
triethyl pentane-1,3,5-tricarboxylate

: 1312919-72-4
diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium / ethanol; toluene / 8 h / 90 °C / Inert atmosphere

2: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 1 h / Inert atmosphere

3: hydrogen / isopropyl alcohol / 2 h / Reflux

4: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; hydrogen; sodium; sodium carbonate; triethylamine; In ethanol; dichloromethane; water; isopropyl alcohol; toluene; 1: Dieckmann reaction;
DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

: 58660-59-6
Diethyl cyclohexanone-2,4-dicarboxylic ester

: 1312919-72-4
diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 1 h / Inert atmosphere

2: hydrogen / isopropyl alcohol / 2 h / Reflux

3: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; hydrogen; sodium carbonate; triethylamine; In ethanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1016/j.ejmech.2011.04.011