4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid

Base Information

Chemical Name:4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid
CAS No.:1312919-90-6
Molecular Formula:C₂₆H₂₃FN₂O₇S
Molecular Weight:526.542
Hs Code.:

Synonyms:4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid

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Chemical Property of 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid

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Technology Process of 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid

There total 8 articles about 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1312919-72-4
diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate

: 1312919-90-6
4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid

Guidance literature:: diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; pH=2; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

: 63579-89-5
triethyl pentane-1,3,5-tricarboxylate

: 1312919-90-6
4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium / ethanol; toluene / 8 h / 90 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 1 h / Inert atmosphere

3.1: hydrogen / isopropyl alcohol / 2 h / Reflux

4.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

5.1: lithium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere

5.2: pH 2 / Inert atmosphere

With hydroxylamine hydrochloride; hydrogen; sodium; sodium carbonate; triethylamine; lithium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; isopropyl alcohol; toluene; 1.1: Dieckmann reaction;
DOI:10.1016/j.ejmech.2011.04.011

Reference yield:

: 58660-59-6
Diethyl cyclohexanone-2,4-dicarboxylic ester

: 1312919-90-6
4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 1 h / Inert atmosphere

2.1: hydrogen / isopropyl alcohol / 2 h / Reflux

3.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere

4.2: pH 2 / Inert atmosphere

With hydroxylamine hydrochloride; hydrogen; sodium carbonate; triethylamine; lithium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1016/j.ejmech.2011.04.011