Technology Process of 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid
There total 8 articles about 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethyl 4-(6-(4-cyano-2-fluorobenzyloxy)naphthalene-2-sulfonamido)cyclohexane-1,3-dicarboxylate;
With
lithium hydroxide;
In
1,4-dioxane;
at 20 ℃;
Inert atmosphere;
With
hydrogenchloride;
In
water;
pH=2;
Inert atmosphere;
DOI:10.1016/j.ejmech.2011.04.011
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium / ethanol; toluene / 8 h / 90 °C / Inert atmosphere
2.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 1 h / Inert atmosphere
3.1: hydrogen / isopropyl alcohol / 2 h / Reflux
4.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere
5.1: lithium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere
5.2: pH 2 / Inert atmosphere
With
hydroxylamine hydrochloride; hydrogen; sodium; sodium carbonate; triethylamine; lithium hydroxide;
In
1,4-dioxane; ethanol; dichloromethane; water; isopropyl alcohol; toluene;
1.1: Dieckmann reaction;
DOI:10.1016/j.ejmech.2011.04.011
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 1 h / Inert atmosphere
2.1: hydrogen / isopropyl alcohol / 2 h / Reflux
3.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere
4.1: lithium hydroxide / 1,4-dioxane / 20 °C / Inert atmosphere
4.2: pH 2 / Inert atmosphere
With
hydroxylamine hydrochloride; hydrogen; sodium carbonate; triethylamine; lithium hydroxide;
In
1,4-dioxane; ethanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1016/j.ejmech.2011.04.011