Cbz-ΔGlu(OMe)-OH

Base Information

• Chemical Name: Cbz-ΔGlu(OMe)-OH
• CAS No.: 96658-32-1
• Molecular Formula: C₁₄H₁₅NO₆
• Molecular Weight: 293.276
• Mol file: 96658-32-1.mol

Synonyms:Cbz-ΔGlu(OMe)-OH

Chemical Property of Cbz-ΔGlu(OMe)-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-ΔGlu(OMe)-OH

There total 6 articles about Cbz-ΔGlu(OMe)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl γ-methyl-α-(N-benzyloxycarbonyl)-α-dehydroglutamate (96658-30-9) → Cbz-ΔGlu(OMe)-OH (96658-32-1)

Guidance literature:

With McIlvaine buffer; 2-hydroxyethanethiol; papain; at 35 ℃; Product distribution; other N-protected α-dehydroglutamic acid diesters and their analogs; war. pH, reaction times and concentration of enzyme and substrate;

DOI:10.1246/bcsj.64.3575

Reference yield: 80.0%

methanol (67-56-1) + (Z)-2-Benzyloxycarbonylamino-pent-2-enedioic acid (116447-43-9) → Cbz-ΔGlu(OMe)-OH (96658-32-1,125705-41-1)

Guidance literature:

With thionyl chloride; In diethyl ether; Ambient temperature;

DOI:10.1016/S0040-4039(00)98474-0

Reference yield: 80.0%

methyl γ-methyl-α-(N-benzyloxycarbonyl)-α-dehydroglutamate (96658-30-9) → Cbz-ΔGlu-OH (96658-31-0) + Cbz-ΔGlu(OMe)-OH (96658-32-1) + Cbz-ΔGlu-OMe (131840-52-3)

Guidance literature:

With calcium chloride; at 35 ℃; for 8h; α-chymotrypsin A, McIlvaine buffer; selective enzymatic hydrolysis;

DOI:10.1246/cl.1990.2089

upstream raw materials:

methyl γ-methyl-α-(N-benzyloxycarbonyl)-α-dehydroglutamate

methanol

(Z)-2-Benzyloxycarbonylamino-pent-2-enedioic acid

α-ketoglutaric acid

Downstream raw materials:

2-(N-Cbz-amino)-5-hydroxy-2-pentenoic acid

(E)-4-Benzyloxycarbonylamino-4-carbamoyl-but-3-enoic acid methyl ester

(E)-4-Benzyloxycarbonylamino-4-thiocarbamoyl-but-3-enoic acid methyl ester

methyl 2-(N-Cbz-amino)-5-hydroxy-2-pentenoate