N-{(1S,2R,3S,4R)-4-[2-((1S,3R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Base Information

Chemical Name:N-{(1S,2R,3S,4R)-4-[2-((1S,3R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide
CAS No.:884652-89-5
Molecular Formula:C₃₁H₃₈N₈O₃
Molecular Weight:570.695
Hs Code.:

Synonyms:N-{(1S,2R,3S,4R)-4-[2-((1S,3R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

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Chemical Property of N-{(1S,2R,3S,4R)-4-[2-((1S,3R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

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Technology Process of N-{(1S,2R,3S,4R)-4-[2-((1S,3R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

There total 16 articles about N-{(1S,2R,3S,4R)-4-[2-((1S,3R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 955969-22-9
{(R)-1-[9-((1R,2S,3R,4S)-2,3-dihydroxy-4-propionylamino-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester trifluoroacetate

: 884652-89-5
N-{(1S,2R,3S,4R)-4-[2-((1S,3R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃;

Reference yield:

: 884653-95-6
carbonic acid (1S,4R)-4-(2,6-dichloro-purin-9-yl)-cyclopent-2-enyl ester ethyl ester

: 884652-89-5
N-{(1S,2R,3S,4R)-4-[2-((1S,3R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

3: dichloromethane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

5: diisopropylamine / tetrahydrofuran / 2 h / 50 °C

6: dimethyl sulfoxide / 100 °C

7: hydrogenchloride; methanol / 20 °C

With hydrogenchloride; methanol; diisopropylamine; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 884653-96-7
di-boc-[(1S,4R)-4-(2,6-dichloro-purin-9-yl)-cyclopent-2-enyl]-amine

: 884652-89-5
N-{(1S,2R,3S,4R)-4-[2-((1S,3R)-3-amino-pyrrolidin-1-yl)-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Guidance literature:: Multi-step reaction with 6 steps

2: dichloromethane / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

4: diisopropylamine / tetrahydrofuran / 2 h / 50 °C

5: dimethyl sulfoxide / 100 °C

6: hydrogenchloride; methanol / 20 °C

With hydrogenchloride; methanol; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;