N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Base Information

Chemical Name:N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide
CAS No.:884652-29-3
Molecular Formula:C₂₇H₂₉ClN₆O₃
Molecular Weight:521.019
Hs Code.:

Synonyms:N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Suppliers and Price of N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

There total 12 articles about N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (lS,2R,3S,5R)-3-amino-5-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-cyclopentane-1,2-diol trifluoroacetate

: 79-03-8
propionyl chloride

: 884652-29-3
N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 884653-99-0
N-[(1S,2R,3S,4R)-4-(2,6-dichloro-purin-9-yl)-2.3-dihydroxy-cyclopentyl]-propionamide

: 3963-62-0
2,2-Diphenylethylamine

: 884652-29-3
N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 50 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: 884653-95-6
carbonic acid (1S,4R)-4-(2,6-dichloro-purin-9-yl)-cyclopent-2-enyl ester ethyl ester

: 884652-29-3
N-{(1S,2 R,3S,4R)-4-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

3: dichloromethane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

5: diisopropylamine / tetrahydrofuran / 2 h / 50 °C

With diisopropylamine; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dichloromethane;