Technology Process of 2-benzyloctahydropyrano[3,4-c]pyrrole
There total 5 articles about 2-benzyloctahydropyrano[3,4-c]pyrrole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(1-benzyl-4-(hydroxymethyl)pyrrolidin-3-yl)ethanol;
With
dmap; triethylamine; p-toluenesulfonyl chloride;
In
toluene;
at 20 ℃;
for 12h;
Inert atmosphere;
With
triethylamine;
In
toluene;
for 4h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridinium chlorochromate / dichloromethane / 8 h / Reflux
2.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C
3.1: lithium borohydride / tetrahydrofuran / 7 h / 0 - 20 °C / Inert atmosphere
3.2: 16 h / Reflux
4.1: p-toluenesulfonyl chloride; dmap; triethylamine / toluene / 12 h / 20 °C / Inert atmosphere
4.2: 4 h / Reflux
With
dmap; lithium borohydride; triethylamine; p-toluenesulfonyl chloride; pyridinium chlorochromate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C
2.1: lithium borohydride / tetrahydrofuran / 7 h / 0 - 20 °C / Inert atmosphere
2.2: 16 h / Reflux
3.1: p-toluenesulfonyl chloride; dmap; triethylamine / toluene / 12 h / 20 °C / Inert atmosphere
3.2: 4 h / Reflux
With
dmap; lithium borohydride; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; toluene;
