(2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester

Base Information

Chemical Name:(2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester
CAS No.:188966-66-7
Molecular Formula:C₃₄H₃₂N₂O₅
Molecular Weight:548.638
Hs Code.:

Synonyms:(2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester

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Chemical Property of (2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester

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Technology Process of (2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester

There total 6 articles about (2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 98-88-4
benzoyl chloride

: 188966-65-6
(2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester

: 188966-66-7
(2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester

Guidance literature:: In pyridine; 0 deg C to room temperature;
DOI:10.1016/S0960-894X(97)00068-1

Reference yield:

: 171336-72-4
(2R,4R)-1-benzyl-2-ethoxycarbonylpyrrolidine-4-spiro-5'-hydantoin

: 188966-66-7
(2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 20percent Pd(OH)2/C / methanol / 2 h / 750.06 Torr

2: 48 percent / 6 N HCl / 27.5 h / Heating

3: TsOH / toluene / Heating

4: 63 percent / Et₃N / CH₂Cl₂

5: 71 percent / pyridine / 0 deg C to room temperature

With hydrogenchloride; hydrogen; toluene-4-sulfonic acid; triethylamine; palladium dihydroxide; In pyridine; methanol; dichloromethane; toluene;
DOI:10.1016/S0960-894X(97)00068-1

Reference yield:

: 100-44-7
benzyl chloride

: 188966-66-7
(2R,4R)-4-Benzoylamino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / Et₃N / CH₂Cl₂

2: 71 percent / pyridine / 0 deg C to room temperature

With triethylamine; In pyridine; dichloromethane;
DOI:10.1016/S0960-894X(97)00068-1